Unknown "no_cache" variable nginx

The issue might be caused by outdated custom vhost templates created on 17.5. Plesk 17.8 brings new features, so in case you have custom vhost templates from 17.5 configuration templates for domains will be generated incorrectly.

Pre-upgrade checker verifies such situation, so you should have the corresponding warning from Plesk before the upgrade.

Solution:
If you have anything in /usr/local/psa/admin/conf/templates/custom/ then move these files out and reconfigure Apache + Nginx:

Clean up Plesk db from current errors:
# plesk db "delete from Configurations where status <> 'ok';"

Recreate configuration:
# plesk repair web

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